Delta

Delta significantly associates patients without a known mechanism of resistance to those with one to suggest alterative treatment options based on the known MoR through an analysis of the changes in alterations between timepoints.

Method

The entire ReVeaL pipeline can be executed by:

calculate_patient_delta_predefined(df, pair_df)	Function to calculate the Delta per predefined pair of samples
calculate_patient_delta_sliding_window_driver(df, ...)	Function to calculate Deltas over a matrix of patients
calculate_patient_delta_sliding_window(df, ...)	Function to calculate Delta and produce a matrix of sample pairs and the delta values for a given patient given a window size

Citation

Please cite the following article if you use Delta:

Parikh, A.R., Leshchiner, I., Elagina, L. et al. Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med 25, 1415–1421 (2019). https://doi.org/10.1038/s41591-019-0561-9